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ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will raise the level or impact of ergotamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Acute ergot toxicity characterised by vasospasm and tissue ischemia has become linked to coadministration of ritonavirKeep track of Carefully (1)crofelemer boosts amounts of ergo